Institute for Functional Materials Chemistry

 

About project

The project is aimed at meeting the needs of the diagnostic technology market, as well as addressing urgent issues in veterinary medicine related to low bioavailability and rapid release of active substances.
The project plans to develop and investigate new supramolecular systems based on biologically active substances and fluorescent compounds, which will have improved operational characteristics compared to existing analogs. This will enhance the sensitivity and reliability of medical-biological research using fluorescence methods, as well as improve bioavailability and ensure prolonged release of active substances in veterinary medicines.
The project also includes the establishment of a new infrastructure unit at the SSI "Institute for Single crystals" of the NAS of Ukraine, which will involve the acquisition of equipment, creation of a center for the collective use, and organization of scientific events to promote supramolecular chemistry in Ukraine.

The goal of the project

Development of new materials for biomedical and veterinary applications based on supramolecular systems of the host-guest, rotaxane and pseudorotaxane types, as well as other topologies using cucurbiturils, cyclodextrins and their modified analogues as receptors.

Main tasks of the project Research team of the project: Dr. Yana Sakhno, Dr. Natalia Pinchukova, PhD student Daria Miasnikova, Dr. Olga Kolosova, Dr. Olesia Kulyk (top row, from left to right), Dr. Oleksandr Zbruyev, Prof. Dr. Valentyn Chebanov, PhD student Rostyslav Svoiakov (bottom row, from left to right.)

Research team of the project: Dr. Yana Sakhno, Dr. Natalia Pinchukova, PhD student Daria Miasnikova, Dr. Olga Kolosova, Dr. Olesia Kulyk (top row, from left to right), Dr. Oleksandr Zbruyev, Prof. Dr. Valentyn Chebanov, PhD student Rostyslav Svoiakov (bottom row, from left to right.)

Scientific tasks:

  1. To develop methods for the synthesis of new supramolecular systems based on bioactive and fluorescent compounds
  2. To investigate the spectral, photophysical and photochemical properties of rotaxane and pseudorotaxane dyes and establish correlations with their supramolecular structure.
  3. To study the effect of pH, temperature and other factors on the stability and release kinetics of the active substance from the obtained supramolecular complexes.
  4. To develop methodologies for biomedical testing of the obtained complexes.
  5. To refine the synthesis methods of supramolecular systems developed during the project
  6. 6. To design prototypes of materials for biomedical and veterinary purposes based on the obtained supramolecular systems.

Tasks for developing an infrastructure unit:

  1. To purchase and install equipment and take measures to create a center for collective use.
  2. To organize a seminar, school-conference and trainings.
  3. To carry out measures to promote the project.