Kharkiv Chemical Seminar

During russia's war against Ukraine, many Ukrainian scientists have no opportunity to carry out their research in laboratories and participate in scientific conferences. However, it is very important for them to get in touch with colleagues and to be involved in scientific processes. For this reason, we have organized online chemistry seminars for Ukrainian scientists - Kharkiv Chemical Seminar - and approach leading chemists to give lectures there.

Lecturer: Prof. Radek Cibulka (University of Chemistry and Technology, Czech Republic)

Lecture:Deazaflavin-based strong reducing agents produced by light
Date: December 8th
Time: 16:00 (Kyiv)

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Meeting ID: 459 004 2894
Passcode: Ch24022022

Chairman: Prof. Valentyn Chebanov

Lecture abstract:

 Within the last few years, the interest increased in the development of strong reducing organic agents with reducing power comparable to sodium and lithium and with a significantly less hazard potential. Such reducing agents could be used as alternatives in various chemical transformations where alkaline metals still play a key role. The combination of light with a suitable dye is one promising way to achieve this goal. Nevertheless, the number of reducing systems as strong as alkaline metals are still limited and not all of the systems work catalytically. In the presentation, development of catalytic reductive systems based on flavin derivatives working on principles of photoredox catalysis will be presented. Excited radical anions and neutral radicals derived from deazaflavins dFl and analogous deazaalloxazines were shown to belong among the strongest reducing particles characterized by excited state oxidation potential achieving values below -3.3 V vs SCE, value comparable to lithium (Eox = -3.29 V vs SCE). Practical applications including e.g. phenyl radical generation from halobenzenes, photoreductive triflyl/tosyl group removal from sulphonamides or amine group dealkylation will be discussed. Strongly reducing properties of flavin derivatives developed within last three years clearly show that flavins belong among the most versatile photoredox catalysts covering also reductions, additionally to previously described oxidations.

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Scheduled lecturers

Dr. Philippe Gros, University of Lorraine
Prof. Orlando Rojas (The University of British Columbia)
Two days course of lectures: Perspectives in Chemistry: Molecular, Supramolecular, Adaptive Chemistry
Prof. Jean-Marie Lehn, University of Strasbourg, Nobel Prize Winner, Professor of Chemistry at Institute for Advanced Study
Artificial Intelligence: the Future for Synthetic Chemistry?
Prof. Alexandre Varnek, University of Strasbourg, Head of the Laboratory of Chemoinformatics
Controlling self-assembly by chemical fuels
Prof. Thomas Hermans, Professor of Chemistry at the University of Strasbourg
Cyclisation reactions of free and masked dianions
Prof. Peter Langer, University of Rostock, Head of the Department of Organic Synthesis, Director of the Institute of Chemistry